Prof. Ian Henderson

Institute for Molecular Bioscience, University of Queensland, Victoria, Australia

Career Summary: Qualifications: B.Sc. (Hons) University College Dublin 1990, Ph.D. Trinity College Dublin 1996, PGCertLTHE University of Birmingham 2002.

Current roles: Deputy Director Research; Institute of Molecular Biology, University of Queensland 2018-present, Professor of Microbial Biology; Institute of Microbiology and Infection, University of Birmingham, 2015-present.

Research Philosophy: My research interests focus on the bacterial cell surface. This focus is based on the philosophy that the bacterial cell surface offers a rich source of molecules, which can be utilized and adapted to treat or prevent infections. Currently we have four major themes exploiting a range of experimental techniques to address fundamental questions in the biology of host-pathogen interactions: (1) We use biochemical and biophysical methodologies to study the biogenesis of a group of proteins termed auto transporters, (2) we use structural, biochemical and biophysical techniques to understand the basis for outer membrane biogenesis, (3) we use molecular biology, cellular biology and immunological methodologies to study the roles outer membrane proteins play in the interaction of pathogens with their hosts and (4) we utilize genome sequencing to appreciate the diversity and repertoire of surface proteins among gram-negative bacteria with a view to developing novel intervention strategies.

Current Research Grants (All values Full Economic Cost where applicable)

2019-2022, Biotechnology and Biological Sciences Research Council, £500,000 (IRH – coPI)

2017-2021, EU Marie Curie ITN, (Train2Target) £3,495,000 (IRH – coPI)

2016-2019, Medical Research Council, £890,906 (IRH – PI)

2016-2023, Wellcome Trust, £5,400,000 (IRH – PI)

2015-2018, Australian Research Council, £203,000 (IRH – coPI)

2015-2020, Biotechnology and Biological Sciences Research Council, £730,000 (IRH – PI)

2014-2019, Biotechnology and Biological Sciences Research Council, £1,350,554 (IRH – PI)

2015-2019, Wellcome Trust, £250,000 (IRH – coPI)

Career research achievements: H-index=52; >10,800 total cites

Top 5 publications in the last 5 years

1. Goodall ECA, A Robinson, IG Johnston, S Jabbari, KA Turner, T Hitchcock, AF Cunningham, PA Lund, JA Cole, IR Henderson*. 2018. The essential genome of Escherichia coli K-12. MBio. 9: e02096-17

2. Wells TJ, J Davison, E Sheehan, S Kanagasundaram, G Spickett, CA MacLennan, RA Stockley, AF Cunningham, IR Henderson* and A De Soyza. 2017 The use of plasmapheresis in patients with bronchiectasis with Pseudomonas aeruginosa infection and inhibitory antibodies. Am J Respir Crit Care Med. 195: 955-958

3. Wells TJ, D. Whitters , YR Sevastsyanovich, JN Heath, J Pravin, M Goodall, D Browning, MK O'Shea, A Cranston, A De Soyza, AF Cunningham, CA MacLennan, IR Henderson* and R Stockley. 2014. Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing. J. Exp. Med. 211: 1893-904.

4. Leyton DL, YR Sevastsyanovich , DF Browning , AE Rossiter , TJ Wells , RE Fitzpatrick , M Overduin , AF Cunningham and IR Henderson*. 2011. Size and Conformation Limits to Secretion of Disulfide-bonded Loops in Autotransporter Proteins. J. Biol. Chem. 286: 42283-91.

5. Rossiter AE, DF Browning, DL Leyton, MD Johnson, RE Godfrey, CA Wardius, M Desvaux, AF Cunningham, F Ruiz-Perez, JP Nataro, SJW Busby and IR Henderson*. 2011. Transcription of the plasmid-encoded toxin gene from Enteroaggregative Escherichia coli is regulated by a novel co-activation mechanism involving CRP and Fis. Mol. Microbiol. 81: 179-91.